https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44648 2NPs) is on the increase, and so the number of studies dedicated to describing this material's biological effects. Previous studies have presented results indicating the controversial impact of TiO₂NPs on cell fate regarding death and survival. We speculate that this may be due to focusing on each of the subject cells as an isolated individual. In this study, we made a difference by looking at the subject cells as an interrelated population. Specifically, we exposed mesenchymal stem cells (MSCs) to TiO₂NPs and observed cell death and stimulation of proliferation among the cell population. Our data shows that the exposure to TiO₂NPs initiated autophagy, which led to an increase in extracellular Wnt protein levels and increased Wnt/GSK3β/β-catenin/cyclin D1 signalling in the cell population. Autophagy inhibitor repressed the effects of TiO₂NPs, which indicates that ß-catenin regulation was dependent on TiO₂NPs-induced autophagy. The inhibition of β-catenin resulted in dysregulation of cyclin D1 protein expression level. In conclusion, following exposure to TiO₂NPs, MSCs undergo autophagy, which induces cell proliferation among the cell population by upregulation of cyclin D1 through the Wnt/GSK3β/β-catenin pathway.]]> Wed 19 Oct 2022 09:00:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29868 Wed 15 Dec 2021 16:08:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38201 Wed 11 Aug 2021 10:05:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36270 Thu 17 Jun 2021 16:20:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25924 in vitro treatment with Fgf7 protein increased coiling of WDs. In summary, our work has established that epithelial canonical Wnt signalling is a critical regulator of WD coiling and its precise regulation is essential for WD/epididymal differentiation.]]> Sat 24 Mar 2018 07:27:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33850 Fri 18 Jan 2019 14:48:51 AEDT ]]>